Nandrolone Dosage Guide + Max Dose, Adjustments

If abused, we have seen orals cause peliosis hepatis (blood-filled cysts) or cirrhosis (failure) of the liver. Following treatment, 72% reported a reduction in pain, and 28% required less painkiller medication (3), demonstrating the potent anti-inflammatory effects of the steroid. Femara lowers estrogen levels and is used to treat breast cancer in postmenopausal women. Both the National Collegiate Athletic Association (NCAA) and the World Anti-Doping Agency (WADA) include nandrolone on their prohibited lists. The organization prohibits performance-enhancing drugs that may endanger athletes. Even when taken at the appropriate doses, nandrolone can cause heart failure and liver damage.

Nandrolone: Package Insert / Prescribing Info

The anabolic-androgenic steroids are a family of hormones abused by athletes because of their well-known properties on increasing muscle mass and strength, and among them ND is the most used one.
There is also a severe decrease in the number of HDL 2 and 3 particles overall, which are generally regarded as being atheroprotective.
However, nandrolone decanoate remains available from compounding pharmacies in the United States, for instance AnazaoHealth.
You won’t see a ton of mass within a short time period like something along the lines of an Oxymetholone (Anadrol), but you’re going to get real high quality gains over a decent period of time.
Aggressiveness is a common finding in AAS abusers, among other psychiatric disorders 87, and this has been confirmed by several studies on animals 88,89,90,91,92,93.

To date most experimental studies have been conducted on animal models, because it would be unethical to administer high doses of AASs over prolonged periods of time. Moreover, the habit of polydrug abuse makes it hardly possible to distinguish the toxic effects of AASs from those caused by other drugs 138. In addition, a general limitation of human studies is the fact that data about the modality and doses of AAS use/abuse are often self-reported. Lastly, the susceptibility of individuals is influenced by genetic factors that are well known as key factors in developing adverse events 139. Virilization in female users is a well-known side effect, characterized by voice pitch alteration, body hair growth, hair loss, thick and greasy skin, acne, as well as increased libido and clitoris hypertrophy 54. Recent studies in animal models have identified a potential role for nandrolone in joint pain, particularly post rotator cuff tears (31,32).

There are two primary choices in anti-estrogens, Selective Estrogen Receptor Modulators (SERM’s) like Nolvadex (Tamoxifen Citrate) and Aromatase Inhibitors (AI’s) like Arimidex (Anastrozole). AI’s will be far more effective, but SERM’s should be the first choice if they can get the job done. Many choose to rely on AI’s due to their tremendous anti-estrogenic power, but AI’s have been noted to have a negative impact on cholesterol, and one that can be greatly exasperated with the use of anabolic steroids. Conversely, while SERM’s are sometimes not enough they will have no adverse effect on cholesterol.

How is Nandrolone supplied

It is closely related to testosterone structurally but has a number of important pharmacological differences in comparison. These differences include inactivation by 5α-reductase rather than potentiation, less or no conversion into estradiol, and much greater progestogenic activity. The inactivation of nandrolone by 5α-reductase results in nandrolone theoretically having much lower androgenic strength than testosterone in skin, hair follicles, and the prostate, among other tissues. Consequently, nandrolone may have less propensity for oily skin, acne, facial/body hair growth, scalp hair loss, and prostate problems than testosterone.

Nowadays, especially athletes in power sports such as bodybuilding and weightlifting administer illegally high doses of AASs to increase their muscle mass and improve their overall performance 24. Nandrolone decanoate (ND) injection has been classified as a Schedule III controlled substance under the Anabolic Steroids Control Act of 1990 25. Due to serious health risks, the nonmedical use of AASs is banned by most sports organizations.

In one such study by Gerber et al. (31), 20 New Zealand white rabbits had their supraspinatus tendon released with musculotendinous retraction and observed over 6 weeks. Rabbits were organized into groups treated with placebo as well as local and systemic administration of nandrolone (31). Nandrolone, given in the phase after tendon release, was found to inhibit fatty infiltration of the supraspinatus muscle and reduced functional impairment of the rotator cuff (31).

Several studies highlighted that prolonged androgen exposure has a direct toxic effect on kidneys, especially glomerular cells, causing the accumulation of mesangial matrix, podocyte depletion and structural adaptations 118,119. A recent report suggested that ND exposure promotes hypertrophy in proximal and distal convoluted tubules of mice kidneys 120. Moreover, both testosterone activity and ND direct action to AR may play a role in the genesis of kidney fibrosis after long-term ND exposure 121. The molecular mechanism underlying this altered tendon activity may be related to collagen synthesis 60,110. Hassager and colleagues concluded that anabolic steroids stimulate type III collagen synthesis, which affects muscular tissues as well as bone tissues 111.

Dutasteride has similar or greater effectiveness than finasteride for scalp hair loss in men (Arif et al., 2017), whereas it hasn’t yet been studied in the treatment of hirsutism (Wiki). It shows higher affinity for the AR than does testosterone and has almost no binding affinity for sex hormone-binding globulin (SHBG) however. For these reasons, nandrolone has about 2.5- to 5-fold higher potency than testosterone in rats on measures of general AR agonistic strength, such as stimulation of muscle growth (Sundaram et al., 1995; Tóth & Zakár, 1986; Wiki; Winters, 1976).

Finally, nandrolone administration in mice confirmed the up-regulation of stemness-markers in liver, spleen and kidney. HDL-C has been reported to significantly decrease after a 200 mg starting dose of nandrolone and a further 100 mg/wk for a total of 8 weeks in male bodybuilders 97. Although in a similar design and population, 200 mg/wk of nandrolone for 8 weeks resulted in no significant change in HDL-C 98. No effect was observed on LDL-C, TGs, Apo Oxymetholone in USA A1 or Apo B levels in the above studies 97–99.